Non-invasive multi-sensor wearable system to estimate acute changes in glucose level in type 1 diabetes

The self-monitoring of blood glucose (SMBG) is a significant part of glucose management for T1D patients. A relationship between frequent SMBG and glycaemic control measured by HbA1c has been observed previously. The typical SMBG meter involves finger-pricking to obtain blood from the capillaries. Disadvantages of using such an invasive method include pain, discomfort, and risk of infection. In addition, with this discrete measurement, the changes in glucose level might be missed.

The awareness of the changes in glucose level can be impaired in T1D patients, so they may lose the ability to sense low blood glucose. Although there are glucose monitoring devices available for continuous estimation of plasma glucose level, they are still invasive and often painful. Therefore, a genuine need for a way to non-invasively monitor glucose level exists within the diabetic community.